Structural studies and antifungal activity of unique polyene amides, clathrynamide A and three new derivatives, from a marine sponge, Psammoclemma sp.
نویسندگان
چکیده
Known polyene amide, clathrynamide A, and three novel related metabolites, debromoclathrynamide A, (4E,6E)-debromoclathrynamide A and (6E)-clathrynamide A, were isolated from an Okinawan marine sponge, Psammoclemma sp. The absolute stereochemistry of clathrynamide A was determined to be 3R,12R by the modified Mosher method. The structures of the three new compounds were elucidated by spectroscopic analyses as debromo derivatives and geometrical isomers. Their antifungal activities were also evaluated with a phytopathogenic fungus, indicating that both the bromine atom and double-bond geometry affected the activity.
منابع مشابه
Structural Studies and Antifungal Clathrynamide A and Three New Psammoclemma Sp . Activity of Derivatives JSX Unique Polyene Amides
cins,6'ii) and curromycins.i2'i]) In our search for novel antifungal metabolites from marine organisms, 1 was rediscovered from an Okinawan marine sponge of Rsammoclemma sp. as a potent antifungal substance. In addition to 1, we have found three new related metabolites, debromoclathrynamide A (2), (4E,6E)-debromoclathrynamide A (3), and (6E)clathrynamide A (4). This paper reports the first dete...
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ورودعنوان ژورنال:
- Bioscience, biotechnology, and biochemistry
دوره 67 7 شماره
صفحات -
تاریخ انتشار 2003